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Macrophages employ quorum licensing to regulate collective activation
2020
Nature Communications
Macrophage-initiated inflammation is tightly regulated to eliminate threats such as infections while suppressing harmful immune activation. However, individual cells' signaling responses to pro-inflammatory cues are heterogeneous, with subpopulations emerging with high or low activation states. Here, we use single-cell tracking and dynamical modeling to develop and validate a revised model for lipopolysaccharide (LPS)-induced macrophage activation that invokes a mechanism we term quorum
doi:10.1038/s41467-020-14547-y
pmid:32054845
pmcid:PMC7018708
fatcat:4wtvdr6eavgxvkvxcgutw576su