THE THERAPEUTIC EFFECTS OF CEFOTAXIME ON VARIOUS INFECTIOUS DISEASES IN CHILDREN
小児各種感染症に対するCefotaximeの治療効果

YOHEI NISHIBAYASHI, MITSUNORI HAMAWAKI, HIROSHI OZAKI, ISAMU KITAMURA
1980 Chemotherapy  
Clinical application to ascertain the effect of cefotaxime upon several infections of childhood was performed. Nine cases of acute pneumonia, 7 of urinary tract infection (UTI), 3 of tonsillitis, 2 of purulent meningitis, 2 of peritonitis, 2 of cervical lymphadenitis, one each of subcutaneous abscess and acute periodontitis were selected, as clinical and/or bacteriological data could be followed up. Cefotaxime that contains 500 mg or 1 g was used in two ways, i.e., one shot i.v. injection and
more » ... ipinfusion. Dose of the drug ranged from 50 mg to 200 mg/kg/day and was administered for 2-14 days. The evaluation of the effect was calculated as follows : Cardinal symptom(s) which disappeared within 3 days were considered "excellent" within 5 days "good", after more than 5 days "fair", and no change of clinical symptoms was considered "poor". Bacteriological results were expressed as "eliminated" "partially reduced", "unchanged" and "undetermined". Cefotaxime was used in a total of 27 patients, and clinical efficacy obtained was excellent in 10 cases, good in 26 and poor in 1. The efficacy rate was 96.3%. Of these patients the drug's efficacy was good to excellent in 9 out of 9 cases of acute pneumonia, good to excellent in 7 out of 7 cases of UTI, good in 1 case and poor in 1 case out of 2 cases of purulent meningitis, excellent in 1 case and good in 1 case out of 2 cases of peritonitis, good to excellent in 3 out of 3 cases of tonsillitis, excellent in 1 case and good in 1 case out of 2 cases of lymphadenitis, and excellent in the sole cases of both subcutaneous abscess and acute periodontitis studied. With respecit to cefotaxime's bactereriological efficacy, results were good in 6 cases and unchaged in 3 cases of acute pneumonia, good in 4 cases, fair in 1 case, and undetermined in 2 cases of UTI, good in 1 case and unchanged in 1 case of purulent meningitis, good in 1 case and undetermined in 1 case of peritonitis, good in all 3 cases of tonsillitis, undetermined in 1 case and unchanged in 1 case of lympha denitis, and good in one case each of subcutaneous abscess and acute periodontitis. Bacteria to which the lowest MIC of the drug observed is H. influenzae and the highest MIC observed is S. epidermidis. Results of the clinical and bacteriological observations were paralleled to this MIC test. No clinical side effects and/or abnormal laboratory findings during and after the administration of this drug were noted.
doi:10.11250/chemotherapy1953.28.supplement1_560 fatcat:awajvtmyrjfd3lggbumjwlicbq