Stem cells, signals and vertebrate body axis extension

V. Wilson, I. Olivera-Martinez, K. G. Storey
2009 Development  
The progressive generation of chick and mouse axial tissuesthe spinal cord, skeleton and musculature of the body -has long been proposed to depend on the activity of multipotent stem cells. Here, we evaluate evidence for the existence and multipotency of axial stem cells. We show that although the data strongly support their existence, there is little definitive information about their multipotency or extent of contribution to the axis. We also review the location and molecular characteristics
more » ... ar characteristics of these putative stem cells, along with their evolutionary conservation in vertebrates and the signalling mechanisms that regulate and arrest axis extension.
doi:10.1242/dev.039172 fatcat:ln3zzhbz2nhqhe427t2qygy4cm