Substrate specificity of an oxygen dependent sulfoxide synthase in ovothiol biosynthesis

Gabriel T. M. Mashabela, Florian P. Seebeck
2013 Chemical Communications  
OvoA is an iron(II) dependent sulfoxide synthase which catalyzes the first step in ovothiol A biosynthesis. This enzyme sulphurizes the C 5 position of the imidazole side chain of L-histidine. We report the substrate specificity profile of this catalyst and present data which indicate that OvoA catalysis follows an thiol-ene type mechanism.
doi:10.1039/c3cc42594k pmid:23877651 fatcat:fu6tsojj2zaotmh5utqni3alna