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Non-autonomous regulation of bone mass accrual and the role of T-cell protein tyrosine phosphatase in the bone regulation of insulin sensitivity
The skeleton is a highly dynamic organ that undergoes constant remodeling to renew itself and maintain bone mass. It is subject to regulation from both hormones produced in peripheral tissues and neuronal control by the nervous system. Recent studies have shown that the skeleton is also an endocrine organ, releasing the hormone osteocalcin that increases insulin secretion and sensitivity in the pancreas and testosterone production in the Leydig cells of the testis. In my thesis study, I exploredoi:10.7916/d8f47w70 fatcat:3xzrfbal3fejlhdzbvyptsnrja