Taking Genetics of Amyotrophic Lateral Sclerosis to Next Steps

Orla Hardiman
2015 US Neurology  
Great advances have been made in understanding the genetics of amyotrophic lateral sclerosis, but we are really merely at the end of the beginning. Many new genes have been discovered, but these need to be contextualized within populations and across different phenotypes. Increased international collaboration through whole-genome sequencing initiatives, such as Project MinE (www.projectMinE.com), combined with detailed clinical phenotyping is most likely to drive future research in disease
more » ... rch in disease pathogenesis and new drug development
doi:10.17925/usn.2015.11.02.108 fatcat:f4lebsfydfd7tfpk232fxstsny