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Great advances have been made in understanding the genetics of amyotrophic lateral sclerosis, but we are really merely at the end of the beginning. Many new genes have been discovered, but these need to be contextualized within populations and across different phenotypes. Increased international collaboration through whole-genome sequencing initiatives, such as Project MinE (www.projectMinE.com), combined with detailed clinical phenotyping is most likely to drive future research in diseasedoi:10.17925/usn.2015.11.02.108 fatcat:f4lebsfydfd7tfpk232fxstsny