Enlightening Point of View Based on Potassium Channel "Origami Windmill" Model
Journal of US-China Medical Science
Applying the K + channel origami windmill model principle, the whole process of action potential generation of nerve fiber cells and cardiomyocytes is explained reasonably. Its core view is: cell action potential decline phase, dominated by influx of potassium ions. This is contrary to the core idea of the traditional theory-ionic theory. According to ionic theory, cell action potential decline phase, is dominated by outflow of K + ions. In the face of such two opposing views, the author traces
... , the author traces back to the source, combing and commenting on the basic theoretical research on the production mechanism of cell bioelectricity generation and the results of classical basic experiments. And a series of enlightening viewpoints are produced: (1) ionic theory has its preexistence deficiency; (2) There are principle defects in Goldman-Hodgkin-Katz(GHK) equation and Hodgkin-Huxley(H-H) equation; (3) ion channels may be "same direction sharing"; (4) sodium-potassium pumps, calcium pumps and so on may not exist. The thesis's point is falsifiable. If "cell action potential decline stage, dominated by outflow of K + ions" can be proved, all the points in this paper will not be true. On the contrary, the series of enlightening views in this paper will inevitably lead to a revolution in the field of life science. The viewpoint of this paper is not only closely related to the causes of human major diseases, treatment principles and methods, but also may have a profound impact on the future research direction of life scienceresearchers. So the author suggests that scholars in the field of life science should re-sort out the existing bioelectricity knowledge system to eliminate the false, save the truth and clear the source, especially focusing on the papers published by Hodgkin and Huxley in 1952; at the same time, it is necessary to reevaluate the scientificity and scientific value of membrane theory, ionic theory, GHK equation and H-H equation, and put forward new theories based on Bernstein membrane theory, establishing a new mathematical model of cell action potential.