THU0662 THE FREQUENCY OF MULTIPLE MYELOMA IN PATIENTS WITH ELEVATED ACUTE PHASE RESPONSE AND LOW BACK PAIN IN A RHEUMATOLOGY OUTPATIENT CLINIC

Fulya Cosan, Yavuz Furuncuoglu, Meis Timuroglu, Mohammed Raid Oyiwe, Osman Kara
2019 Poster Presentations   unpublished
A recent study showed that the risk of ankylosing spondylitis (AS) was increased in patients with uveitis.(1) Objectives: The study aimed to test the risk of psoriasis (PsO), Crohn's disease (CD), ulcerative colitis (UC) and AS in uveitis patients. Methods: The data source of this study was the 2003-2012 claims data from the Taiwanese National Health Insurance Research Database. We identified 4,943 incident patients with uveitis defined as having ! 2 ambulatory or !1 inpatient visits with a
more » ... nosis of ICD-9-CM 360.12, 364.00-364.02, 364.04-364.05 or 364.3 made by an ophthalmologist from 2006 to 2012 after excluding those having prior PsO (ICD-9-CM 696.1), PsA (ICD-9-CM 696.0), CD (ICD-9-CM 555), UC (ICD-9-CM 556) or AS (ICD-9-CM 720) and randomly selected 49,430 non-uveitis individuals matching (1:10) uveitis cases for age, sex and the year of the index date from a one million representative population. We estimated the incidence rates of PsO (diagnosed by dermatologists), CD, UC and AS for the uveitis and non-uveitis cohorts, and the incidence rate ratios (IRR) and hazard ratios (HRs) after adjusting for sex, age, Charlson comorbidity index and concomitant medications. Results: No incident case of CD was identified in uveitis patients and non-uveitis individuals. Compared with non-uveitis individuals, patients with uveitis had significantly higher incidence rates of PsO (IRR, 8.82; 95% CI, CD (IRR, 7.23; 95% CI,) and AS (IRR, 171.69; 95% CI,). However, after adjusting for potential confounders, uveitis patients had a significantly higher risk of developing PsO and AS, but not CD. Conclusion: This nationwide, population-based cohort study revealed that uveitis patients had an increased risk of PsO and AS, but not CD.
doi:10.1136/annrheumdis-2019-eular.7878 fatcat:xgfzgreuuvf5rm2253faryimtq