Probiotics, living microorganisms which when used in adequate amounts, have health benefits on the host, have attracted a considerable deal of interest in the biotechnology market. Various prokaryotic and eukaryotic microbes have been studied for probiotic purposes in human and animals. Lactobacillus and Bifidobacterium are the main probiotic genera; however, there are reports on the probiotic potential of strains belonging to Bacillus, Lactococcus, Pediococcus and also some yeast species.

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... bacillus species are regarded as the most investigated beneficial microbes for human and either animal probiotic development due to: a) anti-inflammatory effects, b) anti-allergic features, c) secretion of antimicrobial compounds, d) develops in aerobic and anaerobic conditions, and e) many Lactobacilli have been Generally Recognized As Safe (GRAS) by the Food and Drug Administration (FDA). Among Lactobacilli, Lactobacillus rhamnosus Gorbach-Goldin (GG) is known among the most in-detail studied strains and is regarded as a top well-researched and commercialized probiotic strain in the industrial biotechnology. Strain GG is a commercially significant probiotic which was originally isolated from the healthy human gastrointestinal tract in 1983. The documents studied this strain were reviewed here and it is shown that such successful strains in the probiotic market have been extensively studied from the probiotic traits and safety point of views and a minor part of the documents concerned the bioprocessing issues. Also, we showed that the beneficial and negative effects of this strain has been investigated in various clinical trial systems when it became commercialized. Various aspects of this strain are here reviewed, comparatively.