Dual-kV is a spectral CT modality that is currently available clinically, which traditionally employs energy integrating detectors, and in some cases acquire spectral data that is unregistered. A spectral method developed for photon-counting detectors, the constrained one-step spectral CT image reconstruction method (cOSSCIR), is designed to perform material decomposition directly from a set of spectral measurements. As such, the spectral sinograms need not be registered. Within the framework

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... cOSSCIR, dual-kV data is just two-window spectral CT. Furthermore, reconstructing unregistered data, such as that acquired by fast kV switching and slow kV switching systems, provides a potential extension of sOSSCIR to reconstructing clinical data. In this investigation we demonstrate cOSSCIR on unregistered dual-kV protocols using simulations and experimental phantom studies. Our results suggest that cOSSCIR can accurately recover the basis material maps using slowand rapid-kV data compared to fully registered reconstructions.