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Inflammasomes are multi-protein complexes that induce inflammation upon sensing of stress factors. They are composed of a sensor protein with different structures, such as NLRP1 (NLR (NOD-like receptor) family pyrin domain containing 1), the adaptor protein ASC and the effector protease caspase-1. When activated, the sensor induces oligomerization of ASC monomers, termed ASC specks, which activate caspase-1. Caspase-1 in turn cleaves the pro-inflammatory cytokines interleukin (IL)-1β, IL-18 anddoi:10.3929/ethz-b-000601888 fatcat:fzhm7yp7yffzfdvedyrdioftl4