NLRP1 activation in human keratinocytes cultivated in organotypic skin cultures induces a psoriasis-like phenotype [thesis]

Michela Di Filippo, Sabine Werner, Helmuth Gehart, Hans-Dietmar Beer
Inflammasomes are multi-protein complexes that induce inflammation upon sensing of stress factors. They are composed of a sensor protein with different structures, such as NLRP1 (NLR (NOD-like receptor) family pyrin domain containing 1), the adaptor protein ASC and the effector protease caspase-1. When activated, the sensor induces oligomerization of ASC monomers, termed ASC specks, which activate caspase-1. Caspase-1 in turn cleaves the pro-inflammatory cytokines interleukin (IL)-1β, IL-18 and
more » ... gasdermin D (GSDMD) into their mature and active forms. N-terminal GSDMD forms pores in
doi:10.3929/ethz-b-000601888 fatcat:fzhm7yp7yffzfdvedyrdioftl4