Internet Archive Scholar

NLRP1 activation in human keratinocytes cultivated in organotypic skin cultures induces a psoriasis-like phenotype [thesis]

Michela Di Filippo, Sabine Werner, Helmuth Gehart, Hans-Dietmar Beer
2023

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (272.4 kB)
https://web.archive.org/web/20230311173743/https://www.research-collection.ethz.ch/bitstream/handle/20.500.11850/601888/Abstract_29112.pdf;jsessionid=D408BBB6DF2FA42732398597D2B88281?sequence=6

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2023; you can also visit the original URL. The file type is application/pdf.

Inflammasomes are multi-protein complexes that induce inflammation upon sensing of stress factors. They are composed of a sensor protein with different structures, such as NLRP1 (NLR (NOD-like receptor) family pyrin domain containing 1), the adaptor protein ASC and the effector protease caspase-1. When activated, the sensor induces oligomerization of ASC monomers, termed ASC specks, which activate caspase-1. Caspase-1 in turn cleaves the pro-inflammatory cytokines interleukin (IL)-1β, IL-18 and
more » ... gasdermin D (GSDMD) into their mature and active forms. N-terminal GSDMD forms pores in
doi:10.3929/ethz-b-000601888 fatcat:fzhm7yp7yffzfdvedyrdioftl4
Citation

Michela Di Filippo, Sabine Werner, Helmuth Gehart, Hans-Dietmar Beer. "NLRP1 activation in human keratinocytes cultivated in organotypic skin cultures induces a psoriasis-like phenotype." (2023)