Formulation Design and Evaluation of Controlled Release Zolmitriptan Rapimelts
Journal of comprehensive pharmacy
Aim The purpose of this study was to prepare controlled release Zolmitriptan rapimelts. These rapimelts are in the form of Tablets which were prepared by direct compression. Method Ethyl cellulose polymer is used to prepare minimatrices which further converted to micromatrices. Micromatrices were evaluated for different parameters such as drug content, flow properties, percentage yield, moisture content, taste evaluation and drug release. Based on the drug content and drug release optimized
... lease optimized formulation of ethyl cellulose were used to prepare rapimelts. The physicochemical compatibility of the drug with other excipients used in the formulations was studied by FTIR analysis. Results The results obtained showed no physicochemical incompatibility between the drug and other excipients used in the formulations. The prepared Tablets were evaluated for different parameters such as thickness, weight variation, hardness, friability, drug content, disintegration time, water absorption ratio, wetting time, dispersion time and wetting volume. The Tablets were also evaluated for in vitro drug release in 0.1N HCl for 24hrs in USP Type II dissolution apparatus. Conclusion In order to determine the mode of release, the data was fitted into various kinetic models and the optimized formulations followed Krosmeyer peppas model and Higuchi model respectively and n values less than 0.5which indicates Fickian diffusion mechanism of drug release.