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Our server, CLICK: http://mspc.bii.a-star.edu.sg/ click, is capable of superimposing the 3D structures of any pair of biomolecules (proteins, DNA, RNA, etc.). The server makes use of the Cartesian coordinates of the molecules with the option of using other structural features such as secondary structure, solvent accessible surface area and residue depth to guide the alignment. CLICK first looks for cliques of points (3-7 residues) that are structurally similar in the pair of structures to bedoi:10.1093/nar/gkr393 pmid:21602266 pmcid:PMC3125785 fatcat:yaqulndc4bb6dcg7uv6nahpapi