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Nongenetic Control of Receptor Signaling Dynamics with a DNA-based Optochemical Tool [post]

Ryosuke Ueki, Shota Hayashi, Masaya Tsunoda, Momoko Akiyama, Hanrui Liu, Tasuku Ueno, Yasuteru Urano, Shinsuke Sando
2020 unpublished

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Optochemical tools that can modulate activity of the target protein provide an opportunity for studying and regulating the related biological processes. Here we present a DNA-based nongenetic optochemical tool that can control dynamics of growth factor signaling. A photo-caged DNA aptamer for a growth factor receptor was designed to assemble into an active dimer form, depending on UV irradiation, thereby enabling optical control of the dimerization and subsequent activation of the receptor.
more » ... photo-caged mimicry of growth factor can be a promising tool for elucidating a linkage between dynamics of signaling and resulting biological outcomes, as well as for manipulating cellular functions and the fate of living cells.
doi:10.26434/chemrxiv.11533506 fatcat:gp4vpciy4ja5dgsyndcxvxbhcu
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Ryosuke Ueki, Shota Hayashi, Masaya Tsunoda, Momoko Akiyama, Hanrui Liu, Tasuku Ueno, Yasuteru Urano, Shinsuke Sando. "Nongenetic Control of Receptor Signaling Dynamics with a DNA-based Optochemical Tool." (2020)