Reduced model of neurotransmitter transport in the presence of generic receptors and transporters

L V Kalachev
2006 Journal of Physics, Conference Series  
An analysis of glutamate spillover on the N-methyl-D-aspartate receptors at the cerebellar glomerulus Cassie S Mitchell, Steve S Feng and Robert H Lee -A reduced model for shock and detonation waves. I. The inert case G. Stoltz -Real time heat sources identification by a branch eigenmodes reduced model E Videcoq, O Quemener, W Nehme et al. -This content was downloaded from IP address 207.241.231.82 on 23/07Abstract. We present a description of a reduction procedure for a model of glutamate
more » ... port in a synaptic cleft in the presence of a finite number of receptors and transporters with different kinetics properties. Under certain conditions a system of equations for glutamate, receptors and transporters concentrations can be substituted by a single equation for glutamate with effective diffusion and modified kinetics term. The results of model reduction are illustrated with an example showing good agreement between the behavior of the original model and the reduced model.
doi:10.1088/1742-6596/55/1/011 fatcat:pyyirkg2zncyndhy6u4cm3bcbi