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AbstractThe human proteome is a major source of therapeutic targets. Recent genetic association analyses of the plasma proteome enable systematic evaluation of the causal consequences of variation in protein levels. Here, we estimated the effects of 1002 proteins on 225 phenotypes using two-sample Mendelian randomization (MR) and colocalization. Of 413 associations supported by evidence from MR, 139 (34%) were not supported by results of colocalization analyses, suggesting that geneticdoi:10.1101/627398 fatcat:ykzrs6vowrd3poty4rvex3niay