The Human Connectome Project's neuroimaging approach

Matthew F Glasser, Stephen M Smith, Daniel S Marcus, Jesper L R Andersson, Edward J Auerbach, Timothy E J Behrens, Timothy S Coalson, Michael P Harms, Mark Jenkinson, Steen Moeller, Emma C Robinson, Stamatios N Sotiropoulos (+4 others)
2016 Nature Neuroscience  
Non-invasive human neuroimaging has yielded many exciting discoveries about the brain. Numerous methodological advances have also occurred, though inertia has slowed their adoption. This paper presents an integrated approach to data acquisition, analysis, and sharing that builds upon recent advances, particularly from the Human Connectome Project (HCP). The "HCP-style" paradigm has seven core tenets: (1) collect multimodal imaging data from many subjects; (2) acquire data at high spatial and
more » ... poral resolution; (3) preprocess data to minimize distortions, blurring, and temporal artifacts; (4) represent data using the natural geometry of cortical and subcortical structures; (5) accurately align corresponding brain areas across subjects and studies; (6) analyze data using neurobiologically accurate brain parcellations; and (7) share published data via user-friendly databases. We illustrate the HCPstyle paradigm using existing HCP datasets and provide guidance for future research. Widespread adoption of this paradigm should accelerate progress in understanding the brain in health and disease.
doi:10.1038/nn.4361 pmid:27571196 fatcat:wwg4h7gmw5eshc5bc3zsmt6zmy