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TGFβ signaling curbs cell fusion and muscle regeneration
AbstractMuscle cell fusion is a multistep process involving cell migration, adhesion, membrane remodeling and actin-nucleation pathways to generate multinucleated myotubes. However, molecular brakes restraining cell–cell fusion events have remained elusive. Here we show that transforming growth factor beta (TGFβ) pathway is active in adult muscle cells throughout fusion. We find TGFβ signaling reduces cell fusion, regardless of the cells' ability to move and establish cell-cell contacts. Indoi:10.1038/s41467-020-20289-8 pmid:33531466 fatcat:sovg2vozordyhcz5nqaicqarqu