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Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway
Journal of Biological Chemistry
Sphingosine, a metabolite of membrane sphingolipids, is generally considered to be cytotoxic for a variety of cell types. However, we have found that sphingosine at low concentrations stimulates DNA synthesis and acts synergistically with known growth factors to induce proliferation of quiescent Swiss 3T3 fibroblasts. Structurally related analogs of sphingosine, such as N-stearoylsphingosine and other long chain aliphatic amines, had no mitogenic effects, suggesting that sphingosine did notpmid:2294122 fatcat:pn2om6kz4fhqdbjhbec2qsvcvu