Left-right patterning: conserved and divergent mechanisms

T. Nakamura, H. Hamada
2012 Development  
The left-right (LR) asymmetry of visceral organs is fundamental to their function and position within the body. Over the past decade or so, the molecular mechanisms underlying the establishment of such LR asymmetry have been revealed in many vertebrate and invertebrate model organisms. These studies have identified a gene network that contributes to this process and is highly conserved from sea urchin to mouse. By contrast, some specific steps of the process, such as the symmetrybreaking event
more » ... nd situs-specific organogenesis, appear to have diverged during evolution. Here, we summarize the common and divergent mechanisms by which LR asymmetry is established in vertebrates. (2006). Early, H+-V-ATPasedependent proton flux is necessary for consistent left-right patterning of nonmammalian vertebrates. Development 133, 1657-1671. Antic, D., Stubbs, J. L., Suyama, K., Kintner, C., Scott, M. P. and Axelrod, J. D. (2010). Planar cell polarity enables posterior localization of nodal cilia and leftright axis determination during mouse and Xenopus embryogenesis. PLoS ONE 5, e8999. Aw, S., Adams, D. S., Qiu, D. and Levin, M. (2008). H,K-ATPase protein localization and Kir4.1 function reveal concordance of three axes during early determination of left-right asymmetry. Mech. Dev. 125, 353-372. Baker, K., Holtzman, N. G. and Burdine, R. D. (2008). Direct and indirect roles for Nodal signaling in two axis conversions during asymmetric morphogenesis of the zebrafish heart. . Multiple pathways in the midline regulate concordant brain, heart and gut left-right asymmetry. Development 127, 3567-3579. Boettger, T., Wittler, L. and Kessel, M. (1999). FGF8 functions in the specification of the right body side of the chick. Curr. Biol. 9, 277-280. Borovina, A., Superina, S., Voskas, D. and Ciruna, B. (2010). Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia. Nat. Cell Biol. 12, 407-412. Brennan, J., Norris, D. P. and Robertson, E. J. (2002). Nodal activity in the node governs left-right asymmetry. Genes Dev. 16, 2339-2344.
doi:10.1242/dev.061606 pmid:22912409 fatcat:zdzb2lay4rhevf2kepm2tbqk6a