Objective: To compare the results of acute organophosphate intoxication with and without pralidoxime treatment. Methods: It is a retrospective study conducted at the Department of Medicine, Department of Pediatric Medicine and Department of Pathology Bahawal Victoria Hospital Bahawalpur from April 2019 to April 2020. It included 241 patients with acute PO poisoning. Blood urea, serum creatinine and cholinesterase levels were determined. One hundred and ninety-six patients were administered

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... doxime with atropine and the remaining 45 were treated with atropine alone. Data were analyzed using SPSS 17. A value of P <0.05 was considered significant. Results: Most of the patients (60.6%) were 21-30 years of age. The male to female ratio was 2: 1. A total of 17 (7.0%) patients died. The shorter time interval from the onset of OP intoxication to initiation of treatment (p = 0.000) and the use of pralidoxime therapy (0.001) were associated with better survival of patients. Three of the 13 patients admitted to the ICU died, all with low serum cholinesterase levels Conclusion: It was observed that the use of Pralidoxime significantly increases the survival of patients in acute organophosphorus poisoning, and low serum cholinesterase levels have a poor prognosis. Key words: serum cholinesterase, pralidoxime, acute organophosphate intoxication.