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Cascade Michael-Aldol reaction: efficient annulation of sulfonamide chalcones into novel cyclohexenones under solvent-free conditions
2016
ARKIVOC
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A simple, convenient and efficient synthesis of novel sulfonamide cyclohexenones from differently substituted sulfonamide chalcones has been developed. Syntheses of cyclohexenones have been achieved via cascade Michael-Aldol reaction under solvent free condition. This process features mild and solvent-free synthesis of the titled compounds with high yields (18 examples, up to 95% yield). The synthesized scaffold is a promising intermediate for the further transformation into various heterocyclic compounds.
doi:10.3998/ark.5550190.p009.488
fatcat:idqcszrtcre3nfpyfm6ms5hkve