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DNA cytosine methylation plays a considerable role in normal development, gene regulation, and carcinogenesis. Hypermethylation of the promoters of some tumor suppressor genes and the associated silencing of these genes often occur in certain cancer types. The reversal of this process by DNA methylation inhibitors is a promising new strategy for cancer therapy. In addition to the four wellcharacterized nucleoside analogue methylation inhibitors, 5-azacytidine, 5-aza-2V -deoxycytidinedoi:10.1158/1535-7163.mct-05-0172 pmid:16227400 fatcat:7tuaz4mcdze3lezd4vl23dbzcm