Mood disorders and circulating levels of inflammatory markers in a longitudinal population-based study

J Glaus, R Von Känel, A M Lasserre, M-P F Strippoli, C L Vandeleur, E Castelao, M Gholam-Rezaee, C Marangoni, E-Y N Wagner, P Marques-Vidal, G Waeber, P Vollenweider (+2 others)
2018
There has been increasing evidence that chronic low-grade inflammation is associated with mood disorders. However, the findings have been inconsistent because of heterogeneity across studies and methodological limitations. Our aim is to prospectively evaluate the bi-directional associations between inflammatory markers including interleukin (IL)-6, tumor necrosis factor (TNF)-and high sensitivity C-reactive protein (hsCRP) with mood disorders. Methods The sample consisted of 3118 participants
more » ... 3118 participants (53.7% women; mean age: 51.0, s.d. 8.8 years), randomly selected from the general population, who underwent comprehensive somatic and psychiatric evaluations at baseline and follow-up (mean follow-up duration = 5.5 years, s.d. 0.6). Current and remitted mood disorders including bipolar and major depressive disorders (MDD) and its subtypes (atypical, melancholic, combined atypical and melancholic, and unspecified) were based on semi-structured diagnostic interviews. Inflammatory biomarkers were analyzed in fasting blood samples. Associations were tested by multiple linear and logistic regression models. Results Current combined MDD [ = 0.29, 95% confidence interval (CI) 0.03-0.55] and current atypical MDD ( = 0.32, 95% CI 0.10-0.55) at baseline were associated with increased levels of hsCRP at follow-up. There was little evidence for inflammation markers at baseline predicting mood disorders at follow-up. Conclusions The prospective unidirectional association between current MDD subtype with atypical features and hsCRP levels at follow-up suggests that inflammation may be a consequence of this condition. The role of inflammation, particularly hsCRP that is critically involved in cardiovascular diseases, warrants further study. Future research that examines potential influences of medications on inflammatory processes is indicated. ABSTRACT 31 Background: There has been increasing evidence that chronic low-grade inflammation is associated with 32 mood disorders. However, the findings have been inconsistent because of heterogeneity across studies 33 and methodological limitations. Our aim is to prospectively evaluate the bi-directional associations 34 between inflammatory markers including Interleukin (IL)-6, Tumor Necrosis Factor (TNF)-α and high 35 sensitivity C-reactive protein (hsCRP) with mood disorders. 36 Methods: The sample consisted of 3,118 participants (53.7% women; mean age: 51.0, s.d. 8.8 years), 37 randomly selected from the general population, who underwent comprehensive somatic and psychiatric 38 evaluations at baseline and follow-up (mean follow-up duration = 5.5 years, s.d. 0.6). Current and 39 remitted mood disorders including bipolar and major depressive disorders (MDD) and its subtypes 40 (atypical, melancholic, combined atypical and melancholic, and unspecified) were based on semi-41 structured diagnostic interviews. Inflammatory biomarkers were analyzed in fasting blood samples. 42 Associations were tested by multiple linear and logistic regression models. 43 Results: Current combined MDD (β=0.29, 95% CI: 0.03-0.55) and current atypical MDD (β=0.32, 95% CI: 44 0.10-0.55) at baseline were associated with increased levels of hsCRP at follow-up. There was little 45 evidence for inflammation markers at baseline predicting mood disorders at follow-up. 46 Conclusions: The prospective unidirectional association between current MDD subtype with atypical 47 features and hsCRP levels at follow-up suggests that inflammation may be a consequence of this 48 condition. The role of inflammation, particularly hsCRP that is critically involved in cardiovascular 49 diseases, warrants further study. Future research that examines potential influences of medications on 50 inflammatory processes is indicated. 51 52 prospective study; cardiovascular risk factors. 54 364 Achur RN, Freeman WM, Vrana KE (2010). Circulating cytokines as biomarkers of alcohol abuse and 365 alcoholism. Journal of Neuroimmune Pharmacology 5, 83-91. 366 Agosti V, Levin FR (2006). The effects of alcohol and drug dependence on the course of depression. The
doi:10.5167/uzh-168038 fatcat:hu2sz3cycvdexhws54ixmlumde