The New York Islands AVM Study: Design, Study Progress, and Initial Results
and Purpose-Prospective population-based data on the incidence of brain arteriovenous malformation (AVM) hemorrhage are scarce. We studied lifetime detection rates of brain AVM and incident AVM hemorrhage in a defined population. Methods-The New York islands (ie, Manhattan Island, Staten Island, and Long Island) comprise a 9 429 541 population according to the 2000 census. Since March 15, 2000, all major New York islands hospitals have prospectively reported data on consecutive patients living
... ve patients living in the study area with a diagnosis of brain AVM and whether the patient had suffered AVM hemorrhage. Patients living outside the ZIP code-defined study area were excluded from the study population. Results-As of June 14, 2002, 284 prospective AVM patients (meanϮSD age, 35Ϯ18 years; 49% women) were encountered during 21 216 467 person-years of observation, leading to an average annual AVM detection rate of 1.34 per 100 000 person-years (95% CI, 1.18 to 1.49). The incidence of first-ever AVM hemorrhage (nϭ108; mean age, 31Ϯ19 years; 45% women) was 0.51 per 100 000 person-years (95% CI, 0.41 to 0.61). The estimated prevalence of AVM hemorrhage among detected cases (nϭ144; mean age, 33Ϯ19 years; 50% women) was 0.68 per 100 000 (95% CI, 0.57 to 0.79). Conclusions-Our prospective data, spanning 27 months, suggest stable rates for AVM detection and incident AVM hemorrhage. Approximately half of AVM patients may suffer intracranial hemorrhage. (Stroke. 2003;34:e29-e33.) Key Words: cerebral arteriovenous malformations Ⅲ epidemiology Ⅲ hemorrhage T he New York Islands AVM Study is an ongoing, prospective, population-based incidence and case-control study designed to determine arteriovenous malformation (AVM) detection rates, the incidence and prevalence of AVM-associated morbidity, mortality and case fatality rates. Predefined demographic and morphological variables are collected in a multicenter design to analyze their effect on AVM-associated morbidity and mortality.