The New York Islands AVM Study: Design, Study Progress, and Initial Results

C. Stapf, H. Mast, R.R. Sciacca, A. Berenstein, P.K. Nelson, Y.P. Gobin, J. Pile-Spellman, J.P. Mohr
2003 Stroke  
and Purpose-Prospective population-based data on the incidence of brain arteriovenous malformation (AVM) hemorrhage are scarce. We studied lifetime detection rates of brain AVM and incident AVM hemorrhage in a defined population. Methods-The New York islands (ie, Manhattan Island, Staten Island, and Long Island) comprise a 9 429 541 population according to the 2000 census. Since March 15, 2000, all major New York islands hospitals have prospectively reported data on consecutive patients living
more » ... ve patients living in the study area with a diagnosis of brain AVM and whether the patient had suffered AVM hemorrhage. Patients living outside the ZIP code-defined study area were excluded from the study population. Results-As of June 14, 2002, 284 prospective AVM patients (meanϮSD age, 35Ϯ18 years; 49% women) were encountered during 21 216 467 person-years of observation, leading to an average annual AVM detection rate of 1.34 per 100 000 person-years (95% CI, 1.18 to 1.49). The incidence of first-ever AVM hemorrhage (nϭ108; mean age, 31Ϯ19 years; 45% women) was 0.51 per 100 000 person-years (95% CI, 0.41 to 0.61). The estimated prevalence of AVM hemorrhage among detected cases (nϭ144; mean age, 33Ϯ19 years; 50% women) was 0.68 per 100 000 (95% CI, 0.57 to 0.79). Conclusions-Our prospective data, spanning 27 months, suggest stable rates for AVM detection and incident AVM hemorrhage. Approximately half of AVM patients may suffer intracranial hemorrhage. (Stroke. 2003;34:e29-e33.) Key Words: cerebral arteriovenous malformations Ⅲ epidemiology Ⅲ hemorrhage T he New York Islands AVM Study is an ongoing, prospective, population-based incidence and case-control study designed to determine arteriovenous malformation (AVM) detection rates, the incidence and prevalence of AVM-associated morbidity, mortality and case fatality rates. Predefined demographic and morphological variables are collected in a multicenter design to analyze their effect on AVM-associated morbidity and mortality.
doi:10.1161/01.str.0000068784.36838.19 pmid:12690217 fatcat:rfobzp2mvrbipkl2gvddfd2fvi