Hydnora africana Derived Phytochemicals against Acetaldehyde Dehydrogenase of Aeromonas hydrophila Causing Septicemia

Debajani Tripathy, Chandana Adhikari, Mukundjee Pandey, Bhagyeswari Behera, Srimay Pradhan, Akshay Kumar Sahu
2020 Journal of Pharmaceutical Research International  
For drug discovery it takes approximately 6 years to expose in the market and for commercial uses. There are different procedure to get success in the drug discovery like preliminary phytochemical analysis, structural elucidation of the bioactive compound, preclinical test and clinical test etc. So to optimize the time for invention of new drug molecule, computer aided drug designing and molecular docking analysis is being used as one of the highly effective methodology. The phytochemical
more » ... tion of Hydnora africana plant was reported to inhibit the growth of Aeromonas hydrophila which cause Septicemia. "Biovia Discovery Studio" molecular docking methods give us opportunity to identify the effective molecule against the microbes. "High positive values of -CDOCKER energy and -CDOCKER interaction energy" recommended that flavone can effectively deactivate the acetaldehyde dehydrogenase enzyme thereby interrupting the life cycle of the organism.
doi:10.9734/jpri/2020/v32i930539 fatcat:2j2oyvj3kve7jhvpuglidaxmfi