Alix and Syntenin-1 direct amyloid precursor protein and amyloid beta trafficking into extracellular vesicles [post]

2020 unpublished
Endosomal trafficking and amyloidogenic cleavage of amyloid precursor protein (APP) is believed to play a role in the neurodegeneration observed in Alzheimer's disease (AD). Recent evidence has suggested that packaging and secretion of APP and amyloid beta into small extracellular vesicles (EVs) may facilitate uptake of these neurotoxic factors during disease progression. However, the molecular mechanisms underlying trafficking of APP into EVs are poorly understood. Results: In this study, the
more » ... echanism and impact of amyloid precursor protein (APP) trafficking into
doi:10.21203/rs.2.22338/v1 fatcat:h2wrybmch5gr3fsv55uyeoxrby