Host function-dependent induction of defective interfering particles of vesicular stomatitis virus

C Y Kang, R Allen
1978 Journal of Virology  
Suppression of host cell function by treatment with actinomycin D prior to infection prevented the induction of defective interfering particles of vesicular stomatitis virus, which had been cloned and propagated in cells pretreated with actinomycin D. Replication of defective interfering particles already present in an infecting virus stock, however, was not affected by pretreatment of cells with actinomycin D. Thus, the induction, but not the replication, of defective interfering particles
more » ... ering particles appears to be a host cell function-dependent phenomenon. The implications of this phenomenon for host defense mechanisms against virus infections are discussed.
doi:10.1128/jvi.25.1.202-206.1978 fatcat:4cx35xgoujabnpvqn5yamtgowy