Physical separation of DNA according to Royal Road fitness

D. Harlan Wood, Junghuei Chen
Proceedings of the 1999 Congress on Evolutionary Computation-CEC99 (Cat. No. 99TH8406)  
We want to implement evolutionary computation using DNA, with trillions of candidate solutions being simultaneously evaluated for fitness. Unsurprisingly, the most difficult aspect is designing and implementing laboratory methods for physical separation of DNA strands according to "fitness." We propose a DNA strand design suited to the classical Royal Road Problem. And we propose companion laboratory operations which would physically separate these DNA strands according to the Royal Road fitness criterion.
doi:10.1109/cec.1999.782534 fatcat:pjsaakyj6jaepiip3aqlqkgnsm