Histological Changes in Testis of Wistar Albino Rats Following Formaldehyde Exposure by Inhalation
Journal of Clinical and Diagnostic Research
Formaldehyde use remains a crucial occupational hazard, especially for anatomists and pathologists and has long been suspected of causing adverse effects on reproductive organs. Aim: To evaluate the histological changes in the testis of wistar albino rats following formaldehyde exposure through inhalation. Materials and Methods: The toxic effects of formaldehyde were studied by an animal experimental study at the Department of Anatomy, Government Kilpauk Medical College, Chennai, India. The
... nai, India. The study was conducted on 20 wistar albino rats. The rats were divided into five groups of four rats each. The control Group I was not exposed to formaldehyde. The exposure Group II (E1a) and Group III (E1b) were exposed to 1.5 ppm of formaldehyde for seven (6 hours) and twelve (4 hours) weeks respectively. The Group IV (E2a) and Group V (E2b) were exposed to 3 ppm of formaldehyde for seven (6 hours) and twelve (4 hours) weeks respectively. At the end of exposure period, the testis were dissected and observed for gross and microscopic (using haematoxylin and eosin stain) changes.