Enhancing the Informativeness and Replicability of Imaging Genomics Studies

Cameron S. Carter, Carrie E. Bearden, Edward T. Bullmore, Daniel H. Geschwind, David C. Glahn, Raquel E. Gur, Andreas Meyer-Lindenberg, Daniel R. Weinberger
2017 Biological Psychiatry  
Imaging genomics is a new field of investigation that seeks to gain insights into the impact of human genetic variation on the structure, chemistry and function of neural systems in health and disease. As publications in this field have increased over the past decade, increasing concerns have been raised about false positive results entering the literature. Here we provide an overview of the field of imaging genomic and genetic approaches, and discuss factors related to research design and
more » ... sis that can enhance the informativeness and replicability of these studies. We conclude Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript.
doi:10.1016/j.biopsych.2016.08.019 pmid:27793332 pmcid:PMC5318285 fatcat:557jc4nqynffbdmgcq3pigvvdy