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Iterative Modeling Reveals Evidence of Sequential Transcriptional Control Mechanisms
2017
Cell Systems
Combinatorial control of gene expression is presumed to be mediated by molecular interactions between coincident transcription factors (TFs). While information on the genome-wide locations of TFs is available, the genes they regulate and whether they function combinatorially often remain open questions. Here, we developed a mechanistic, rather than statistical, modeling approach to elucidate TF control logic from gene expression data. Applying this approach to hundreds of genes in 85 datasets
doi:10.1016/j.cels.2017.01.012
pmid:28237795
pmcid:PMC5434763
fatcat:g3luu3ecwrappahx2b4dfyslmu