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Modified HIF expression in CD8+ T cells increases anti-tumor efficacy
[article]
2020
bioRxiv
pre-print
Adoptive transfer of anti-tumor cytotoxic T cells is a novel form of cancer immunotherapy, and a key challenge is to ensure the survival and function of the transferred T cells. Immune cell survival requires adaptation to different micro-environments, and particularly to the hypoxic milieu of solid tumors. The HIF transcription factors are an essential aspect of this adaptation, and we undertook experiments to define structural determinants of HIF that would potentiate anti-tumor efficacy in
doi:10.1101/2020.06.18.159137
fatcat:6nl2p4sdgrathemtfjszbabbui