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Non-Uniformity of Projection Distributions Attenuates Resolution in Cryo-EM
Virtually every single-particle cryo-EM experiment currently suffers from specimen adherence to the air-water interface, leading to a non-uniform distribution in the set of projection views. Whereas it is well accepted that uniform projection distributions can lead to high-resolution reconstructions, non-uniform (anisotropic) distributions can negatively affect map quality, elongate structural features, and in some cases, prohibit interpretation altogether. Although some consequences ofdoi:10.1101/635938 fatcat:f7iyql2v6ngfjdanstps4o4w5y