Synthesis and properties of a novel pH sensitive poly(N-vinyl-pyrrolidone-co-sulfadiazine) hydrogel

J. Guo, L. Li, Y. Ti, J. Yhu
2007 eXPRESS Polymer Letters  
Sulfadiazine monomer (SDM) was synthesized by the reaction of sulfadiazine with acryloyl chloride. The SDM was characterized by 1 H-NMR and IR spectra. A novel hydrogel with -SO2NH-group was obtained by the radical copolymerization of SDM with N-vinyl-pyrrolidone (NVP). Effects of the reaction temperature, reaction time, the monomer ratio, and the amount of the cross-linker on the pH sensitivity of the hydrogel were investigated. Results indicate that the hydrogel shows strong pH sensitivity in
more » ... the pH range of 6.5 to 7.2. It also exhibits a good swelling reversibility at buffer solutions of pH 6.5 and 7.2. At last, drugs tests demonstrated the release effect of the hydrogel in pH range of 6.5 to 7.2.
doi:10.3144/expresspolymlett.2007.26 fatcat:367m2hqqgbcdnpjizinsqmgrfi