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Early Host Cell Targets of Yersinia pestis during Primary Pneumonic Plague
2013
PLoS Pathogens
Inhalation of Yersinia pestis causes primary pneumonic plague, a highly lethal syndrome with mortality rates approaching 100%. Pneumonic plague progression is biphasic, with an initial pre-inflammatory phase facilitating bacterial growth in the absence of host inflammation, followed by a pro-inflammatory phase marked by extensive neutrophil influx, an inflammatory cytokine storm, and severe tissue destruction. Using a FRET-based probe to quantitate injection of effector proteins by the Y.
doi:10.1371/journal.ppat.1003679
pmid:24098126
pmcid:PMC3789773
fatcat:ideqfzabkvffzj5vmcyv7yzozm