Seleção de plantas com atividade anticolinasterase para tratamento da doença de Alzheimer

Maria Teresa Salles Trevisan, Fábio Vanderlan Viana Macedo, Michiel van de Meent, In Kyung Rhee, Rob Verpoorte
2003 Química Nova  
Recebido em 12/12/01; aceito em 5/11/02 SCREENING FOR ACETYLCHOLINESTERASE INHIBITORS FROM PLANTS TO TREAT ALZHEIMER'S DISEASE. Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognite impairment and personality changes. The development of drugs for the treatment of the cognitive deficits of AD has focused on agents which counteract loss in cholinergic activities. These symptons of AD have been successfully treated with acetylcholinesterase (AchE) inhibitors (eg.
more » ... mine). There still is great interest in finding better AchE inhibitors. We use Ellmann's microplate assay and silica gel thin-layer chromatography (TLC) to screen natural products from plants as new sources of AchE inhibitors.
doi:10.1590/s0100-40422003000300002 fatcat:wfodzvphdzdtnaceaoxvq2cbjm