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The identification of the primary defect in autosomal dominant polycystic kidney disease (ADPKD) by biochemical methods has proved difficult because of the complexity of the cystic kidney. However, by the use of the genetic method of positional cloning, a gene accounting for -85% of ADPKD, PKD1, has now been identified in the chromosome region lop 13.3. Itsdoi:10.1681/asn.v641125 fatcat:72pkqsbxlrhdhcagi32jhzrjta