Kuehneromycins A and B, Two New Biological Active Compounds from a Tasmanian Kuehneromyces sp. (Strophariaceae, Basidiomycetes)

Gerhard Erkel, Kirsten Lorenzen, Timm Anke, Robert Velten, Alberto Gimenez, Wolfgang Steglich
1995 Zeitschrift für Naturforschung C - A Journal of Biosciences  
In a search for new inhibitors of RNA-directed DNA-polymerases kuehneromycin A (1) was isolated from fermentations of a Tasmanian Kuehneromyces species. Its structure was elucidated by spectroscopic methods. Kuehneromycin A (1) is a non-competitive inhibitor of avian myeloblastosis virus (Ki 200 μᴍ) and moloney murine leukemia virus (Ki 40 μᴍ) reverse transcriptases. The second compound, kuehneromycin B (2) is a strong inhibitor of platelet aggregation stimulated with different inducers. In
more » ... tion, both compounds exhibit cytotoxic and antimicrobial activities.
doi:10.1515/znc-1995-1-202 fatcat:4l6vypnnobhi7fstiklhyq22qi