Long-Term Outcomes of Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia

Hye Won Kwon, Han-Suk Kim, Hyo Soon An, Bo Sang Kwon, Gi Beom Kim, Seung Han Shin, Ee-Kyung Kim, Eun Jung Bae, Chung Il Noh, Jung-Hwan Choi
2016 Neonatology  
Infants with bronchopulmonary dysplasia (BPD) are known to have a high risk of pulmonary hypertension (PH). However, the long-term outcomes of PH in preterm infants with BPD are uncertain. The purpose of this study was to assess outcomes of PH in prematurely born children diagnosed with moderate to severe BPD. Methods: We retrospectively reviewed medical records of patients born before 32 weeks' gestation and diagnosed with moderate to severe BPD from June 2004 to April 2008. Patients were
more » ... ited for a cross-sectional study from August to October 2014 and underwent an echocardiography. Results: Forty-two children were enrolled. Their mean gestational age and birth weight were 26.2 ± 1.7 weeks and 753.1 ± 172.5 g, respectively. Sixteen patients (38%) were diagnosed with PH at a mean age of 3.3 ± 1.6 months, and the PH was improved after a median 12.3 months (range 0.7-46.6 months). Cardiovascular function was reassessed at a mean age of 7.7 ± 0.9 years, at which time 1 patient had been taking a medication for recurrent PH. Conventional two-dimensional and Doppler echocardiography indicated normal ventricular function in all children. However, right ventricular global longitudinal strains decreased in children with previous PH. Conclusions: Subclinical ventricular dysfunction was detectable using v sensitive echocardiographic techniques in children with previous BPDassociated PH. Long-term follow-up and meticulous cardiovascular functional assessment is required in this population. Abstract ·························································································································· i Contents ······················································································································· iii List of tables ··············································································································· iv List of figures ·············································································································· v List of abbreviations and symbols ········································································ vi x PR: pulmonary regurgitation PVR: pulmonary vascular resistance TRV/TVI RVOT : ratio of peak tricuspid regurgitation velocity to right ventricular outflow tract velocity time integral AcT: flow acceleration time
doi:10.1159/000445476 pmid:27172918 fatcat:6zogzc55mza3jmxrzplrhxsl6m