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Pdx1 expression up-regulated by Tet-on system induces the mouse embryonic stem cells to pancreatic-like cells through Notch pathway
[post]
2020
unpublished
Background The specific precursor cells derived from embryonic stem cells (ESCs) after induced differentiation offers great potential for repairing damaged pancreas. Therefore, it is of crucial importance to know whether pancreatic precursor cells with Pdx1+ could be induced to differentiate into pancreatic-like cells in vitro as well as the probable mechanism underlying. Methods In this study, mouse ESCs (ES-E14TG2a) were divided into the blank control group (ESC), the blank vector group
doi:10.21203/rs.3.rs-24808/v1
fatcat:764zneqw5zfmljaje67kaxlh4u