Radiation dose distribution in human kidneys by octreotides in peptide receptor radionuclide therapy

Mark Konijnenberg, Marleen Melis, Roelf Valkema, Eric Krenning, Marion de Jong
2007 Journal of Nuclear Medicine  
Ex vivo autoradiographs of healthy kidney tissue from patients who received (111)In-DTPA-octreotide (DTPA is diethylenetriaminepentaacetic acid) before nephrectomy showed very heterogeneous radioactivity patterns in the kidneys. The consequences of the reported inhomogeneities have been evaluated for radionuclide therapy with (90)Y- DOTA-Tyr(3)-octreotide (DOTA is 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid), (177)Lu-DOTA-Tyr(3)-octreotate, and (111)In-DTPA-octreotide by
more » ... ing dose distributions and dose-volume histograms (DVHs) for the kidneys.
pmid:17204710 fatcat:grexvtu2tfcddigvocprpf4uwm