The purpose of present study is to prepare fast dissolving tablets of domperidone by direct compression. To over come the problems such as difficulty in swallowing, inconvenience in administration during travelling, there is a need to develop fast dissolving tablets of domperidone as an anti emetic.. Domperidone is an anti emetic drug and is having dopamine receptor blocking activity. domperidone tablets were prepared by using different combinations of superdisintegrants and all tablets are

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... uated for different tests like hardness test, friability test, wetting time , In vitro disintegration and In vitro dissolution studies. Tablets containing sodium starch glycolate and microcrystalline cellulose shows optimum results with disintegration time less than 20 sec and drug release was found to be 99 %.