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Hormones function as growth factors, and estrogen provides growth signals to support and induce the proliferation of breast cancers (1-3). This is the basis of the use of endocrine therapies (4, 5) including tamoxifen and letrozole as first-line treatment for patients with breast cancer. We found that the estrogen receptor α (ESR1) was among the genes most differentially expressed in the primary tumors of patients with breast cancer treated with trastuzumab. However, estrogen receptor α wasdoi:10.31219/osf.io/wrhgf fatcat:yaz5vsdkorgsbac3w2urr2ma24