On Variations in the Phagocytic and Coccidal Power of the Blood in Pneumonia and Scarlet Fever

R. Tunnicliff
1911 Journal of Infectious Diseases  
It has been shown by various observers that the phagocytic activity of leukocytes may vary just as the opsonic power of the serum varies, and that it is necessary to examine both leukocytes and serum if one wishes to determine so far as possible the actual capacity of the blood for phagocytosis. Rosenow' found that the leukocytes from pneumonia patients were perceptibly more actively phagocytic than normal leukocytes, as were also leukocytes from patients with puerperal sepsis and appendicitis.
more » ... s and appendicitis. He points out that this is possibly due to the preponderance of young leukocytes. This increased phagocytic power of pneumonic leukocytes seemed to be without reference to the stage of the disease. Potter and Krumwiede found that at the height of streptococcus and pneumococcus infections the phagocytic power of the leukocytes as compared with that of leukocytes of supposedly normal persons was diminished, and more noticeably so than the opsonic index of the serum, but that during recovery the phagocytic power rose well above the normal, and again distanced the opsonic index; during convalescence the phagocytic power of the leukocytes and the opsonic index gradually fell to normal or just below. They made similar observations in staphylococcus infections and tuberculosis. Shattock and Dudgeonobserved that washed 'pneumonic leukocytes were more active than washed normal leukocytes in the serum of three different patients (empyema, urinary fever, and pneumonia), the difference being most marked with pneumonic serum. Achard, Ramond, and Foix' found that the activity of the leukocytes and the opsonic *
doi:10.1093/infdis/8.3.302 fatcat:ltop3x3bure55dq2dguo4hkdvy