Identification of quality markers of Xiaojin Pills using a combination of high-performance liquid chromatographtandem mass spectrometry and multivariate analysis

Xi Xiong, Ya-nan He, Bi Feng, Yuan Pan, Xiu-mei Ke, Li Han, Ding-kun Zhang, Yi Zhang
2018 Tropical Journal of Pharmaceutical Research  
Purpose: To establish an appropriate quality control method for Xiaojin pills using high-performance liquid chromatograph-tandem mass spectrometry combined with multivariate analysis. Methods: High-performance liquid chromatograph-tandem mass spectrometry was established to detect and quantify 13 chemical components of Xiaojin Pills. In order to evaluate the quality difference between diverse specimens of Xiaojin Pills, several multivariate statistical techniques were applied to analyze the
more » ... to analyze the dissimilarity between different batches of samples, including principal composition analysis method and clustering methodology. Results: Five chemical components were identified as primary quality markers, which can be used to accurately distinguish various samples and command the quality of Xiaojin Pills. Conclusion: The results afford a professionally scientific basis for the quality monitoring of Xiaojin Pills and also furnishes reasonable ideas and suggestions for the quality control of other traditional drugs. This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License ( and the Budapest
doi:10.4314/tjpr.v17i8.28 fatcat:zzxcsf4myfcwjnzztzbexh2p7y