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Translating the MAM model of psychosis to humans
2015
Trends in Neurosciences
Elevated dopamine function and alterations in the medial temporal lobe structure and function (MTL) are two of the most robust findings in schizophrenia, but how interactions between these abnormalities underlie the onset of psychosis is unclear. Although several preclinical models of psychosis have been proposed, the methylazoxymethanol acetate (MAM) rodent model provides a mechanistic account linking these two clinical observations. The model proposes that psychosis develops as a result of a
doi:10.1016/j.tins.2014.12.005
pmid:25554679
pmcid:PMC4455929
fatcat:4uonordwmffkhgyfr7zqhbiu2a