Objective: To study the spectrum of optic neuropathies in patient's presenting at AFIO Rawalpindi. Study Design: Descriptive study/retrospective study. Place and Duration of Study: Armed Forces Institute of Ophthalmology, Rawalpindi, from Jan 2017 to Dec 2017. Methodology: Retrospective analysis of hospital record of patients coming to neuro-ophthalmic clinic of ArmedForces Institute of Ophthalmology (AFIO), Rawalpindi, from Jan to Dec 2017 was done. Only patients with clearfinal diagnosis of

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... urophthalmic disease were included. Those with vague diagnosis were excluded. Data wasentered in SPSS version 22 and grouped into variables before analysis. Chi-square test was used for statisticalanalysis. The p<0.05 was considered significant. Results: Forty-five patients were included in study including 33 (73.3%) males and 12 (26.6%) females. Mean age of patients was 41.64 ± 17.74 years. Patients were grouped into ischemic optic neuropathy 20%, toxic optic neuropathies 20%, compressive optic neuropathies 17.7%, inflammatory optic neuropathies 11%, neuroretinitis 6.7%, hereditary optic neuropathies 6.7%, multiple sclerosis (MS) related 4.4%, neuromylitis optics spectrum (NMO-SD) related 4.4%, traumatic optic neuropathies 4.4% and nutritional optic neuropathies 4.4%. Deficiency of vitamin B12 and vitamin D was strongly associated with nutritional optic neuropathies while raised TLC was most common association with inflammatory optic neuropathies (57.14%) and of neuroretinitis (66%). Anti-tuberculosis drugs were most common cause of toxic optic neuropathies (88.88%). Chi square test was used for statistical analysis and p<0.05 was considered significant. Conclusion: Ischemic optic neuropathy is the most common presentation in our population according to ourstudy. However...........