Lipocryolysis is an effective and safe technique for the treatment of localized adiposities. However, there is very little evidence regarding its adverse effects. Materias and Methods: Retrospective analysis of 28 clinical records. Results: The adverse effects of lipocryolysis are mild to moderate, and reversible. Discussion: Specific studies need to be carried out in order to survey adverse effects in a large number of subjects, including medium/long-term follow-up.