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Glycan Ligand Specificity of Killer Lectin Receptors
2012
Yakugaku zasshi
Sialyl Lewis X (sLeX) antigen, Neu5Aca2,3Galb1,4(Fuca1,3)GlcNAc-R, is expressed on the glycoproteins in sera or the surface of the cells and the expression of sLeX is enhanced in various conditions such as the in‰ammation and cancer. SLeX in the serum is utilized as a tumor marker. To clarify the roles of sLeX on secreted glycoproteins in vivo, we investigate the regulation of natural killer (NK) cell-dependent cytotoxicity through sLeX. NK cells express many receptors to kill the target cells
doi:10.1248/yakushi.132.705
pmid:22687729
fatcat:qcqnqdssergrhkkvqxzpvor2bu